Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a combined operation on an hidden munitions depot in Syria operated by the IS group, as stated by the UK Ministry of Defence.
The facility, pinpointed through surveillance, was assessed as storing arms and explosives, the statement said, and was situated in hills just to the north of Palmyra in central Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to target a series of access tunnels down to the facility... preliminary assessments are that the target was engaged successfully," officials stated.
There was no sign of any civilian casualties in the attack late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as ISIS - enforced militant control over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This strike demonstrates our UK leadership, and commitment to operate in unison with allied nations, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the Middle East," Britain's Defence Chief John Healey said.
UK warplanes have conducted patrols over Syrian airspace to "deter any efforts to regroup" of IS subsequent to its defeat at the battle of Baghuz in 2019, the authorities noted.
"I must thank every member of British forces involved in this strike for their professionalism and their courage," the Defence Secretary said. "They were among thousands of British troops stationed over the holidays. This operation, to eliminate dangerous terrorists who pose a risk to our safety, shows how British military are prepared to act, throughout the year, protecting the UK at home and strong abroad."
During December, the American forces conducted what it described as a "massive strike" targeting Daesh sites in the country, subsequent to an assault killed two US servicemembers and a civilian interpreter in the Palmyra area.
The UN says Daesh still maintains an estimated 5,000 to 7,000 combatants in Syria and Iraq.